We develop computational approaches to make sense of genetic variation. And we learn to design biological tools for environmental and human health.

Here we introduce a structured emission distribution (the MuE distribution) that accounts for mutational variability (substitutions and indels) and use it to construct generative and predictive hierarchical Bayesian models (H-MuE models).

PREDICTING PROTEIN STRUCTURES, COMPLEXES, AND CONFORMATIONAL PLASTICITY FROM EVOLUTION

Here, we used multiplexed, sequencing-based assays to measure the effects of 2,695 VKOR missense variants on abundance and 697 variants on activity in cultured human cells.