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https://images.squarespace-cdn.com/content/v1/6399e309a0a4654bff7e7c1b/1671029681474-G07A50WLFASVFOEJIK3X/MarksLabHomepage_proto3_gradient.png Home Page 2.0 (slider) - WHAT WILL WE DO WHEN THERE ARE A BILLION GENOMES? We develop computational approaches to make sense of genetic variation. And we learn to design biological tools for environmental and human health. https://images.squarespace-cdn.com/content/v1/6399e309a0a4654bff7e7c1b/1671029681487-SM9RZ47UTUHNTJ82Z1FI/F1.large.jpg Home Page 2.0 (slider) - Generative probabilistic biological sequence models that account for mutational variability Here we introduce a structured emission distribution (the MuE distribution) that accounts for mutational variability (substitutions and indels) and use it to construct generative and predictive hierarchical Bayesian models (H-MuE models). https://images.squarespace-cdn.com/content/v1/6399e309a0a4654bff7e7c1b/1671029681464-M2FPY7SQZV63UT09USMC/couplings.jpg Home Page 2.0 (slider) - EVOLUTIONARY COUPLINGS PREDICTING PROTEIN STRUCTURES, COMPLEXES, AND CONFORMATIONAL PLASTICITY FROM EVOLUTION https://images.squarespace-cdn.com/content/v1/6399e309a0a4654bff7e7c1b/1671029681481-EIJ0NG6BPQ1E0H73PHHP/Screenshot+2021-02-10+163944.png Home Page 2.0 (slider) - Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact Here, we used multiplexed, sequencing-based assays to measure the effects of 2,695 VKOR missense variants on abundance and 697 variants on activity in cultured human cells.